Dysfunctional Thalamus-Related Networks in Schizophrenia
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چکیده
منابع مشابه
SCHIZOPHRENIA IN TRANSLATION Dysfunctional Thalamus-Related Networks in Schizophrenia
Thalamus abnormalities are common in neurological and psychiatric illnesses. Therefore, it is essential to understand the properties of the thalamus-related networks. The thalamic reticular nucleus (TRN) is a thin GABAergic layer interface strategically located between the thalamus and the neocortex. It is, at the very beginning of life, an essential neurodevelopmental guide for the accurate bu...
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Our understanding of brain function has developed considerably since the advent of cognitive neuroscience and functional neuroimaging. Apparently, there are two central principles that functional brain architectures conform to: functional specialisation and functional integration. The former posits that brain systems are specialised for various perceptual and cognitive functions, and the latter...
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CONTEXT Neural plasticity in the human cortex involves a reorganization of synaptic connections in an effort to adapt to a changing environment. In schizophrenia, dysfunctional neural plasticity has been proposed as a key pathophysiological mechanism. OBJECTIVE To evaluate neural plasticity in unmedicated and medicated patients with schizophrenia compared with healthy subjects. DESIGN Neura...
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BACKGROUND Explaining the diversity of symptoms that occur in schizophrenia is a major conceptual challenge. Perhaps the most powerful strategy is to identify a fundamental cognitive process and/or a fundamental neural circuit. METHODS Convergent data from our research group in Iowa and from investigators in other centres are summarized. RESULTS The thalamus plays a key role in information ...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2011
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbq165